2.1 Cardiovascular and endothelial health The effects of Pycnogenol on cardiovascular and endothelial health have been investigated more than any other health condition with ten human clinical RDP studies ( As the endotheliumthe inner lining of blood vesselsis actively involved in many physiological functions, like controlling blood pressure, blood clotting and signaling during inflammation, endothelial function is crucial for cardiovascular health ( High blood pressure (hypertension) increases the risk of cardiovascular problems, such as heart attack or stroke
Editorial: new drug targets for proteotoxicity in cardiometabolic diseases
The relationship between GSH levels and cognitive function, using the Montreal Cognitive Assessment (MoCA), was interrogated by half (2/4) the MRS studies, and no significant association was found in the ROIs investigated, namely medial frontal (Hupfeld et al., 2021), sensorimotor (Hupfeld et al., 2021) and occipital (Emir et al., 2011)
The synthetic triterpenoid compound bardoxolone methyl (bardoxolone) has also been studied for potential therapeutic applications in various diseases, such as in clinical trials for the treatment of chronic kidney disease, type 2 diabetes, and Alport syndrome [460,461,462,463]
doi: 10.31782/IJCRR.2020.122322 91 MartiNBouchouchaNSauterK-SFlckCE
