95% CI, 0.77 to 0.98), stroke by 18% (HR, 0.82
TMAO reduces bile acid pools, inhibiting FXR activity, disrupting bile acid-FXR signaling, and upregulating pathways worsening hepatic steatosis, as confirmed in HFD-fed C57BL/6J mice and human samples (154)
That this finding was only observed in the DLPFC (and not the ACC) in our cohort is in line with research observing frontal cortical thinning in blast exposed veterans (59), decreased activity (60), and white matter damage (61) in the PFC following mTBI
Redox-Responsive HAGSH Scaffolds for Immune Modulation and Advanced Wound Therapy
For example: Oncology Immunotherapies: Mercks Keytruda (pembrolizumab) is the #1 seller (cancer immunotherapy) and made about $25.0 billion globally in 2023 (roughly half of that from U.S