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heteroatom linkers can also be included in the polyvalent linker L, such as -NR R 2 -, oxygen, sulfur, and the heteroatom linkers may be used to covalently attach any of the radicals described herein, including drug radicals D to the polyvalent linker, ligand radicals B to the polyvalent linker, or various di and polyvalent radicals that from the polyvalent linker L the polyvalent linker L is a releasable linker

Illustrative alkyl groups are, but not limited to, methylene, ethylene, n-propylene, isopropylene, n-butylene, isobutylene, sec-butylene, pentylene, 1,2-pentylene, 1,3-pentylene, hexylene, heptylene, octylene, and the like

10.1016/j.bbamem.2003.12.001 Biochim

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Recommended for individuals with cardiovascular concerns, just one capsule daily after meals maximizes absorption