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4 Safety The maximum dose of catalpol (50 mg/mL) was administered to mice via gavage over 2 weeks, with no signs of acute toxicity or mortality, suggesting that catalpol is safe and non-toxic (Dong et al., 2009)

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Distillation removes minerals and contaminants, but it doesn't sterilize

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58 Franceschi et al in 2018 and Li et al in 2021 outlined the hallmarks of aging, which include: 1) genomic instability, 2) reduced telomere length, 3) epigenetic influences, 4) loss of proteostasis or macromolecular damage 5) deregulated nutrient sensing and metabolic signaling pathways, 6) cellular senescence, 7) stem cell exhaustion, 8) stress and mitochondrial dysfunction and 9) altered intercellular communication