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We need a more transparent process of investigation when serious concerns are raised. Ivan Oransky, co-founder of the blog Retraction Watch , agrees

The wrinkle (no pun intended) is that levels crash as we get older

Persistent synovitis can induce VEGF production, promoting neovascularization and increased vascular permeability (143), which may facilitate the influx of iron into the joint cavity and subchondral bone and recruit additional immune cells, thereby intensifying local oxidative stress and inflammatory cascades (144)

According to the NHS, taking less than 2mg of B12 supplements a day is unlikely to cause any harm

Pregnancy, nursing, and autoimmune conditions warrant particular caution