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294,295 The ATP-dependent proteolytic mechanism operates by the combined effects of three main enzymes: the E1 enzyme activating ubiquitin (Ub), the E2 enzyme for conjugating Ub, and the E3 enzyme for ligating Ub

Integrating UGT inhibition data into the rule-of-two model significantly enhances the prediction accuracy for drug-induced liver injury (DILI) (119)

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