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Mechanistically, the role of KHK in alcohol preference is most likely due to the role of fructose metabolism in the activity levels of aldehyde dehydrogenase (ALDH), the mitochondrial enzyme that metabolizes the toxic intermediate in ethanol metabolism, acetaldehyde

More details on our creation of the OCCT can be found in a previous publication [11]

doi: 10.1146/annurev.nutr.18.1.39 10 HuntleyNFNyachotiCMPatienceJF

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The protein encoded by ACSF2 is partially characterized as mitochondrial acyl-CoA synthetase, which catalyzes the formation of fatty acyl-CoA from ATP, CoA, and medium-chain fatty acids