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Important UK-specific cautions for Pepto-Bismol include: avoid in children under 16 years (risk of Reye's syndrome), avoid in pregnancy and breastfeeding, temporary black discolouration of stools and tongue (which can mask signs of bleeding), and not recommended for longer than 2 days without medical advice

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It also examines the potential of peptides like Epithalon and DSIP in regulating circadian rhythms and improving sleep quality