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Several factors may contribute to variability in reported findings, including differences in DHA dose, duration of exposure, dietary versus biomarker-based assessment methods, control for confounding variables, and background dietary patterns

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Subsequently, a 2026 review in the Journal of the American Academy of Orthopaedic Surgeons classified AOD-9604 as a therapeutic peptide for muscle and cartilage repair, noting that it promotes fat metabolism and may support cartilage repair without markedly altering glucose homeostasis or systemic IGF-1 levels