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When Bifidobacterium and Lactobacillus populations are well-established and fed with prebiotic fibers, they produce SCFAs that signal satiety and reduce the gut-brain signals driving carbohydrate cravings

For many patients, hunger returns, sometimes intensely, and without the drugs support, maintaining the same caloric intake becomes significantly harder

Metabolic and Mitochondrial Research: Supports laboratory investigations into cellular energy regulation, mitochondrial activity, and metabolic signalling pathways

Those human studies were small and short, so the safety picture is encouraging rather than definitive, and its a conversation worth having with a clinician who can weigh it against your own history

J Appl Toxicol 40:151168