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The SURPASS and SURMOUNT trials, which established tirzepatide's efficacy for diabetes and weight management respectively, allowed participants to inject at any time of day on their chosen injection day

What the labeling does say about timing is more useful and more specific: gastrointestinal adverse reactions "were most frequently reported during dosage escalation." The clock that matters is the escalation calendar, not the hour hand

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Namely, the peptide was intended to be used as a sunless tanning agent, but was subsequently found to strongly affect sexual function and appetite [1]

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