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These toxins can alter the gut microbiome, induce DNA damage, and trigger epigenetic changes, all of which can contribute to a misdirected immune response and increase the risk of autoimmune activation

Many oral agents interact with other medications, especially those affecting the liver (CYP enzymes)

The adrenal glands generate hormones such as glucocorticoids, mineralocorticoids, and androgens, ( Figure 1 ) which play significant roles in regulating various physiological processes (55)

Reciprocal regulation of TGF-beta and reactive oxygen species: a perverse cycle for fibrosis