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The 2,2-dimethyl-tetrahydropyran moiety inserts between TM2 and TM3, forming hydrophobic contacts with aliphatic and aromatic residues lining this inter-helical space

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doi: 10.1038/s41591-023-02222-w 90 ChoiHJByunMSYiDChoeYMSohnBKBaekHWet al

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In some cases, providers prescribe both peptides together

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