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Upregulates genes involved in antioxidant defense (superoxide dismutase, catalase), tissue repair (collagen synthesis, matrix metalloproteinases), anti-inflammation (suppressing TNF-, IL-6)
furthermore, this sex difference persisted in female Bmal1 knockout mice that displayed increased core infarct size compared to wild type females (Wiebking et al., 2013)
Every opening and piercing is an opportunity for contamination, even despite the preservative, the principle of minimal handling applies
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