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Impact on Body Weight and Metabolic Health Clinical trials of orforglipron, including ACHIEVE-1, have demonstrated significant reductions in body weight among participants, highlighting its potential as a powerful tool for weight management in diabetes and obesity

Similarly, a study based on swimming exercise for a total of four hours showed an increase in NAD + levels, yet also in this case, no measurements of mitochondrial function were performed 309 , reinforcing the need for more exercise-based investigations to further define how NAD + and mitochondrial homeostasis are perturbed and connected during exercise