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This functional unit strictly depends on the integrity of the gut epithelium, supported by junctional proteins, such as tight junctions (TJs), desmosomes, and adherent junctions, which form a physical barrier and connect adjacent epithelial cells, together with the lamina propria

Moreover, weight cycling has previously been associated with lower muscle mass and strength, as well as an increased risk of SO [99, 100]

Other potential side effects include injection site reactions (redness, itching, swelling), headache , and fatigue

Additionally, reactive oxygen species (ROS), secreted in large amounts by activated microglia, can activate the Rho-kinase pathway, leading to pericyte contraction and inhibition of vasodilation, thus promoting vasoconstriction (Hartmann et al., 2021)

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