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Nevertheless, it is possible that the two processes influence one another
This observation has launched research for the design of novel anti-inflammatory theophylline-like molecules that could be used alone or in combination with corticosteroids, unlocking, again, the steroid resistance that limits its clinical usefulness in emphysema treatment
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For example, the nanoparticle drug PAP-SeNPs constructed from SeNPs and red mushroom polysaccharide component (PAP-1a) can significantly activate the Tlr4/Myd88/NF-B pathway, polarizing M2 macrophages into M1 macrophages thereby activating anti-tumor immune responses (237)
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