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Effectiveness of oral semaglutide in weight loss and glycemic control among type 2 diabetes population: A real-world longitudinal study

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The Summary of Product Characteristics for Mounjaro (tirzepatide) explains that tirzepatide has the potential to impact the rate of absorption of concomitantly administered oral medicinal products and that the impact is most pronounced at the time of tirzepatide treatment initiation. The tirzepatide Patient Information Leaflet advises that if you are pregnant, think you may be pregnant or are planning to have a baby, ask your doctor for advice before using this medicine. While Ozempic and Wegovy contain semaglutide and work by mimicking a hormone called GLP-1 that triggers an increase in the production of insulin, Mounjaro contains the active ingredient tirzepatide, and also acts on a second hormone involved in appetite and blood sugar control

Over-the-counter antidiarrheal medications like loperamide or fiber supplements and osmotic laxatives may be appropriate for short-term use, but you should discuss these options with your healthcare provider before starting them to ensure safe and effective management