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For example, arrhythmias may develop as a result of increased vagal tone and left atrial enlargement

Moreover, pericardial fluid has gained growing interest for the diagnosis and treatment of CVDs due to its anatomical proximity to the myocardium, its low clearance rates and origin as output of plasma ultrafiltration from the epicardial capillaries, secretions from pericardial mesothelial cells and contributions of the myocardial interstitial space 37

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