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Neuroprotection remains a formidable challenge, as every central nervous system (CNS) insult, be it stroke, trauma, or neurodegenerative disease, activates multiple, overlapping injury pathways

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7-10 The latter case was the only study to perform an intradermal skin test to confirm a delayed hypersensitivity reaction to liraglutide, to the authors knowledge

Good candidates for the combination Researchers already using tirzepatide who have plateaued represent the strongest candidates

This absence of comprehensive reporting limits our ability to perform stratified or sensitivity analyses to determine how such interventions may have influenced the observed heterogeneity, particularly in metabolic and hormonal outcomes