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Unlike traditional GLP-1 agonists, which primarily enhance insulin secretion and suppress appetite, Tirzepatide harnesses the additional effects of GIP, further improving metabolic control and promoting weight loss

Bugger H, Abel ED (2009) Rodent models of diabetic cardiomyopathy

Under the MHRA's 'borderline products' guidance, transdermal patches designed to deliver active substances systemically would typically be classified as medicines requiring marketing authorisation

Nausea and diarrhoea are very common, and vomiting is common with GLP-1 receptor agonists according to the SmPC, and can lead to significant fluid loss

translation to human injectable dosing for KLOW indications is unvalidated