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A small-molecule allosteric inhibitor of BAX protects against doxorubicin-induced cardiomyopathy
In some embodiments, the lipid-based drug delivery formulation or composition comprises a penetration enhancer (e.g., a low molecular weight alcohol (e.g., ethanol, oleyl alcohol), alkyl methanol sulphoxides, N-methyl-2-pyrrolidone, fatty amines (e.g., oleylamine), fatty acids (e.g., oleic acid, palmitoleic acid, linoleic acid, myristate acid), gluconic acid (the hexonic acid derived from glucose by oxidation of the aldehyde group at C-1 to a carboxyl group) and its derivatives, such as gluconolactone (especially, glucono-D-lactone, a chelating agent produced by the oxidation of glucose), azone and propylene glycol, singly or in combination)
Currently, dopamine-based therapies such as levodopa are used to alleviate early motor symptoms of PD, but these treatments have significant side effects and do not halt disease progression (Dionsio et al., 2021), yet these mechanisms do not fully elucidate the pathological processes of PD