ERS causes a complete imbalance of intracellular Ca 2+ homeostasis, and the UPR of the cell itself loses its function, eventually leading to apoptosis and autophagy
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Preventive treatment with anti-inflammatory milk fat globule membrane (MFGM) upregulated colonic MUC2, MUC4, Reg3g, and other gene expressions in mice, enhancing mucosal barrier integrity and reducing the risk of microbial-induced intestinal inflammation and secondary liver injury (Wu et al., 2022)
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It is currently unknown whether a lower C4B copy number has a protective effect against the disease or merely reflects an associated pathological protein deficiency
