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Trilling et al , 2011) and HCMV (LeTrilling et al , 2020) induce STAT2 degradation along the ubiquitinproteasome pathway (UPS)

In some embodiments, the otic formulation or composition comprises between about 1% to about 20% by weight of the therapeutic agent, or pharmaceutically acceptable prodrug or salt thereof

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Brief report novel mechanism for valproate-induced teratogenicity

All tissues appear to possess some GSH transferase enzymatic activity, and most have more than one enzyme species - usually a spectrum of isoenzymes that is characteristic of the tissue