A 3-4 day weekly program focused on compound lifts (squats, deadlifts, presses, rows) with progressive overload in the 6-12 rep range at 10-16 hard sets per muscle group weekly is optimal for muscle preservation during GLP-1 therapy
Pinch the skin at the cleaned injection site to create a small fold
It is a sustained intervention that produces cumulative results over months and years
Joshua Silva, MD Nov 7, 2025 13 min read Updated: Apr 17 Medically authored by Joshua Silva, MD | Evidence-Based Weight Loss at Potere Health MD As GLP-1 and GLP-1/GIP medications such as semaglutide (Wegovy, Ozempic) and tirzepatide (Zepbound, Mounjaro) continue to transform medical weight management, one question comes up repeatedly: Do these medications cause muscle lossor even muscle wasting
This is precisely where dangerous mistakes happen, and it is why the dosage calculation process demands your full attention