While telomerase gets the headlines, epigenetic erosion is the silent driver of many age-related diseases, from Alzheimers to cancer to immunosenescence
For experiments involving caspase-3/7 staining, CellEvent Caspase-3/7 Green Detection Reagent (Thermo Scientific C10723) and CPP-CAND were added to live cells 24 h before imaging using an Eclipse Ti-U inverted microscope (NIKON)
As before [ 17 23 ], we noted brain swelling, edema, large intracerebral hemorrhage and intraventricular hemorrhage in the central and lateral ventricles and considerable lesions in all brain areas
Age-specific changes in GSH levels in serum In serum, two studies investigated GSH, GSSG, and/or tGSH in serum of healthy adults, using two techniques (Pardo-Andreu et al., 2006, Prez et al., 2020) (Table 3)
Bacteriostatic Water 3.0 mL per 5 mg vial for reconstitution