Zoeller, Endocrine disrupting chemicals and thyroid hormone action
They can also be taken in order to prevent the central nervous system from getting tired during long workouts
Semaglutide Wegovy / Ozempic Mechanism: GLP-1 receptor agonist (single target) Weight loss: ~15-17% body weight (STEP trials, 68 weeks) Dosing: Weekly injection, titrated from 0.25mg to 2.4mg Common side effects: Nausea, vomiting, diarrhea, constipation (typically transient) Availability: Longer track record, more widely available Cardiovascular data: SELECT trial demonstrated 20% reduction in major cardiovascular events Tirzepatide Zepbound / Mounjaro Mechanism: Dual GLP-1 + GIP receptor agonist (two targets) Weight loss: ~20-22% body weight (SURMOUNT trials, 72 weeks) Dosing: Weekly injection, titrated from 2.5mg to 15mg Common side effects: Similar GI profile to semaglutide
10.1016/j.tplants.2004.08.009 9 NoctorG.QuevalG.MhamdiA.ChaouchS.FoyerC
Additionally, GLP1RAs can enhance endothelial nitric oxide synthase (eNOS) activity and NO production by activating the PI3K/Akt and AMPK-eNOS pathways, thereby improving endothelial-dependent vasodilation in diabetic mice and reducing endothelial inflammation and vascular constriction
![Mechanism of action of GLP-1 [25]](https://www.researchgate.net/publication/256289222/figure/fig1/AS:614177232142337@1523442671231/Mechanism-of-action-of-GLP-1-25.png)
