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Treatment of DIO mice with PYYMK-801 and GIPMK-801 did not affect body weight or food intake beyond that of the parent peptide analogues (Extended Data Fig

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Same was done for the control lag-2(0)

Upon oxidative stress, sudden MPT causes massive ion influx that dissipates mitochondrial membrane potential and shuts down OXPHOS, ATP production and ROS overgeneration

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