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In some subgroups, mood outcomes actually improved alongside metabolic improvements, though researchers noted this may be driven by the physical health changes rather than a direct neurological effect of semaglutide
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High, prolonged cortisol feeds back to the hypothalamus and pituitary in ways that suppress gonadotropin-releasing hormone (GnRH) pulses
They have also stimulated a pipeline of follow-up injectable and oral drugs, as other companies attempt to enter a lucrative market, while Novo and Lilly seek to reinforce their positions as market leaders
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