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This claim builds on research from Harvard published in July 2024, which found a significantly increased risk of NAION among semaglutide users, followed by additional studies in January 2025 and warnings from the Danish Medicines Agency

Recent studies have found that circulating TMAO can promote vascular calcification in rats with CKD and activates the NLRP3 inflammasome and NF-B signaling pathways (Zhang et al., 2020)

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