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Tyr1 and Ile7 of glucose-dependent insulinotropic polypeptide (GIP) confer differential ligand selectivity toward GIP and glucagon-like peptide-1 receptors

The proteins targeted by DPP-4 include: Glucagon Glucagon-like peptide-1 (GLP-1) Glucagon-like peptide-2 (GLP-2) Glucose-dependent insulinotropic polypeptide (GIP) Thus, by inhibiting DPP-4, scientists have been able to raise natural levels of proteins that are useful in diabetes, providing a powerful treatment for managing the condition

Mitochondria in organismal aging and degeneration