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However, in this review article the author will focus on congenital heart defects, due to an increasing evidence of a possible contribution of polymorphisms in folate-pathway genes to their occurrence in the DS offspring (Table 4) coupled with scarce or absence of data for other DS comorbidities

The 40 mg/mL concentration is typically reserved for patients on higher maintenance doses, and it requires extremely careful measurement

Overlapping both drugs simultaneously carries a higher risk of severe GI events and should be avoided