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We found that the endocytosis and dynamin inhibitor dyngo-4A (30 M) (33) abrogated the internalization of FAM(2836), implicating endocytosis as a method of cellular uptake of GLP-1(2836) (Supplemental Figure 6, A and B)

doi: 10.22092/ARI.2021.356628.1884

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These cytokines not only accelerate degradation of the cartilage matrix but also amplify the local inflammatory response via autocrine or paracrine signaling (13)

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