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GLP-1 agonists are typically recommended by NICE for patients with type 2 diabetes who have not achieved adequate glycaemic control on oral agents and meet specific criteria

Figure 1: Scatter Plot and Fitted Line of Change from Baseline in 24-Hour Urinary Glucose Amount versus Dapagliflozin Dose in Healthy Subjects and Subjects with Type 2 Diabetes Mellitus (T2DM) (Semi-Log Plot) Cardiac Electrophysiology Dapagliflozin was not associated with clinically meaningful prolongation of QTc interval at daily doses up to 150 mg (15-times the recommended maximum dose) in a study of healthy subjects

Type 2 Diabetes: Increases the risk of type 2 diabetes and complications due to insulin resistance

Efficacy and acceptability of glycemic control of glucagon-like Peptide-1 receptor agonists among Type 2 diabetes: A systematic review and network meta-analysis

For those initiating GLP-1 therapy in 2021, 33% were persistent, while in the first quarter of 2024, 63% of new initiators were persistent