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A direct correlation between increased metabolism of docetaxel, flutamide, paclitaxel, and mitoxantrone because of increased expression of CYP1B1 (cytochrome P450 1B1) and the onset of MDR in various cancer cells has been drawn out by researchers, as is the case with overexpression of the CYP2A6 (cytochrome P450 2A6) enzyme in breast tumour cells, whereby it is reported to enhance the metabolism of drugs like aflatoxin, cyclophosphamide, ifosfamide, and fluorouracil [54]

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We assume that Novo Nordisk is capable of growing GLP-1 sales across indications from roughly $24 billion in 2023 to nearly $75 billion by 2031, prior to the patent expiration for semaglutide, the molecule in Ozempic and Wegovy