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Clinical trials didnt find tiredness as a side effect, but users are reporting otherwise

The BPI Labs semaglutide guide covers their operations for patients interested in either medication

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[1] [2] Systemic symptoms such as fatigue and headache are also recognised, and these may contribute to a flu-like feeling, especially when combined with reduced caloric intake and the body's adjustment to weight loss

These signals suggest your body isn't getting enough fluid despite tirzepatide suppressing thirst cues