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Conservative dosing initially (in research context) and close follow-up for signs of malignant transformation

There is an increased risk of suicidal thoughts and behaviors in children, adolescents, and young adults taking antidepressants like bupropion XL

We need validated instruments for diagnosing functional GI disorders in patients on these drugs, so that adverse events stop being absorbed into the noise of expected side effects. Perhaps that is simply your doctor assessing your risk for GI disorders before prescription, or maybe they take you off the drug for a few months to see if symptoms subside

Routine high-dose use without medical need is not recommended

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