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Protein available from xCT siRNA-1 showed a significant reduction in xCT expression (30.1%) relative to scramble control levels quantified by western blotting densitometry ( P =0.002) ( Online Supplementary Figure S7B )

Compared to larger peptides, which often struggle with poor bioavailability and proteolytic degradation, tripeptides offer a balance of functional stability and conformational flexibility

While it has been shown that the expression of T-Type Calcium Channel (Schmidt-Hieber et al., 2004) and the expression of the NMDA Receptor 2B subunit (Ge et al., 2007) are involved in mediating their increased plasticity, it remains unknown which additional factors contribute to their unique neurophysiological properties

Blood samples of the dementia patients (age, 7588 y) diagnosed and hospitalized at the National Hospital Organization Ryukyu Hospital, Kin-town, Okinawa were obtained from each patient after informed consent (see Materials and Methods)

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