Severe or Worsening Fatigue Contact your healthcare provider if tiredness is severe enough to interfere with daily activities, work, or self-care, or if fatigue progressively worsens rather than improving as your body adjusts to the medication
They think life is great and theyve lost their first five pounds
179 mg/day) was associated with a 28% lower risk of fatty liver disease in normal-weight women, but no association was found in overweight or obese women or in men
Last reviewed May 16, 2026 by Kim Wohlwend, MSN, APRN, FNP-BC, PMHNP-BC.
One 2025 review in Osteoporosis International found that GLP-1s enhanced bone remodeling and also decreased bone mineral density over time, leaving the authors to raise questions over the possibility of future bone fractures