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Geniposide promotes phosphorylation of brain-derived neurotrophic factor and cAMP response element-binding protein (CREB) by enhancing cholinergic effects, thereby providing neuroprotection ( Therefore, by regulating oxidation, inflammation, apoptosis, and autophagy, these natural products collectively exert neuroprotective and neurotrophic effects, providing a promising treatment for neurodegenerative diseases and injuries
Providing support for a causal link between a negative energy state and increased Parasutterella abundance, a rat model of obesity, which showed similar Parasutterella relative abundances in animals maintained on HFD and those maintained on normal chow but exhibited a treatment-induced increase in Parasutterella relative abundance, displayed a negative correlation between Parasutterella and body weight 82
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Additionally, the microbiomes in these treatment groups were compared to both age-matched lean and obese controls
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