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However, the brain must still be aware of the state of the body so as to precisely coordinate activities that restore homeostasis

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Major Antioxidant: Synthesis and Mechanisms of Action Timbrell, 2009, lists the three principle mechanisms of detoxification with glutathione: 1) Conjugation chemical reaction with glutathione 2) Conjugation catalysed by GSH transferase enzymes 3) Reduction by the donation of a hydrogen atom or proton as a result of oxidation of GSH

Studies tracking radiolabeled peptide demonstrate metabolism primarily in plasma, with resulting amino acids entering normal metabolic pathways