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Medical conditions that reduce response Several conditions can blunt semaglutide effectiveness regardless of whether it is compounded or brand-name: Hypothyroidism , especially untreated or undertreated, slows metabolism and counteracts weight loss Insulin resistance and type 2 diabetes can require higher doses for the same effect PCOS creates hormonal resistance to weight loss interventions Cushing syndrome and other cortisol disorders override appetite suppression mechanisms Certain medications , including some antidepressants, antipsychotics, corticosteroids, and beta-blockers, promote weight gain through independent pathways If you have any of these conditions, semaglutide may still work but could require higher doses or additional interventions
NHS / East Croydon Medical Centre GLP-1 Agonists and Contraception Guidance (2025) 12
The effects on the brain of GLP-1 analogues go far beyond satiety but may also change food preferences in a healthier direction, but also reduce a persons drive for alcohol, tobacco and even opioids
The findings align with prior evidence showing that weight loss can support healthy testosterone levels
Prioritizing protein-rich meals and snacks helps ensure the body has what it needs for muscle retention, even when overall appetite is low
