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Crucially, the structure incorporates a C20 fatty diacid moiety that facilitates albumin binding in laboratory models, protecting the peptide from immediate enzymatic cleavage and extending its reported half-life to approximately 6 days

Generally, the best candidates are women under the age of 60 or within 10 years of menopause onset who have bothersome symptoms, and don't have contraindications to systemic hormone therapy (which include a history of blood clots and certain types of cancer, like breast cancer), according to Faubion

10.3389/fnmol.2017.00175 Front

AOD9604 has also been shown to have shown effects on heart disease through fat reduction and weight loss directly reducing the risk of heart disease

For example, in a 2021 randomized, controlled trial, 100-200mg of dihydroberberine yielded higher blood levels of berberine than 500mg of the standard stuff