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a Dizygotic versus monozygotic b Median SD Distribution and ranges of GSH, GSSG, tGSH, and E hc in MZ and DZ twins The GSH and GSSG levels in freshly collected RBCs from MZ and DZ twins were determined using high performance liquid chromatography with electrochemical detection

Early continuous inhibition of group 1 mGlu signaling partially rescued dendritic spine abnormalities in the Fmr1 knockout mouse model for fragile X syndrome [133]

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The effect typically appears a few months after starting treatment, peaks early, and can last several months before improving as the body adapts

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