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Methods The solid dispersions of docetaxel were prepared in drug:polymer:surfactant ratio of 1:1:0.01 by using different hydrophilic polymers namely, PVP K-30, HPMC E5, PEG 4000, PEG 10000, Eudragit EPO and Eudragit L100, with the surfactant, sodium lauryl sulphate by the technique of freeze-drying

As compared to the wild-type -Thalassemia/HbE patients, the heterozygous UGT1A6*2 without UGT1A1*28 genotype exhibited a reduction in AUC of the free drug and of APAP glucuronide which might be due to UGT1A6*2 polymorphism

The answer is short and simple: We dont know

Some researchers prefer to inject on rest days, as the first 24 to 48 hours after injection tend to produce the most pronounced GI effects