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Activation of GHRH receptors results in the opening of a sodium channel in the somatotrope, leading to its depolarization

GCL-catalyzed conjugation of the -carbonyl group of glutamate with the amino moiety of cysteine is the rate-limiting step in glutathione synthesis

Ipamorelin is a growth hormone (GH) secretagogue that mimics ghrelin and selectively binds the same GHSR-1a receptor as endogenous ghrelin [10]

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The Gq pathway begins with the coupling to phospholipase C (PLC), which converts phosphatidylinositol 4,5-bisphosphate (PIP2) into inositol trisphosphate (IP3) and diacylglycerol (DAG)