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While medications maintain sustained, supraphysiologic hormone levels and typically produce significant weight reduction and HbA1c decreases, food-stimulated GLP-1 is released in brief pulses after meals and rapidly degraded within minutes, resulting in smaller metabolic improvements

Notably, glucagon-like peptide-1 (GLP-1)-based drugs are being successfully used to control glucose levels in patients with diabetes mellitus

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National Cholesterol Education Program (NCEP) expert panel on detection, evaluation, and treatment of high blood cholesterol in adults (adult treatment panel III)

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