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Their use for Alcohol Use Disorder (AUD) or drug addiction is considered "off-label." However, groundbreaking clinical research from 2025 and 2026 demonstrates that these medications significantly dampen the brain's reward centers, drastically curbing cravings for alcohol, opioids, and nicotine

If you want to explore this, talk to your GP and ask them to refer you to an endocrinologist or obesity medicine specialist who is connected to trial networks

In this article, we'll explore the mechanics of these drugs, what to expect if you stop using them, and the steps to take for a safe transition once you've achieved your weight goal

Off-drug weight regain was observed and was accompanied by worsening glycemia and increase in progression to type 2 diabetes. Three-year safety of tirzepatide for weight loss Sean Wharton Sean Wharton, MD, FRCPC, PharmD , medical director of the Wharton Medical Clinic, adjunct professor at McMaster University in Hamilton, Ontario, and York University in Toronto, academic staff at Womens College Hospital and clinical staff at Hamilton Health Sciences, presented the main safety results of the 3-year trial