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Abstract Obesity rates, once thought to be on an inevitable rise with limited treatment options, have recently stabilized and begun to decline in the US, a trend that coincides with the increased use of GLP-1 receptor agonist medications for weight management

Additionally, intracerebroventricular delivery of Ex-4 has been found to dose-dependently attenuate cue-evoked dopamine activity, further underscoring the direct influence of GLP-1R signaling on neural circuits governing reinforcement and motivation (Konanur et al., 2020)

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