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WFS1 encodes an ER resident membrane protein that normally functions to attenuate the ER stress response in cells but increases ER stress and apoptosis when mutated in these cells (185, 221)
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Chertov O, Michiel DF, Xu L, Wang JM, Tani K, Murphy WJ, Longo DL, Taub DD, Oppenheim JJ: Identification of defensin-1, defensin-2, and CAP37/azurocidin as T-cell chemoattractant proteins released from interleukin-8-stimulated neutrophils